A case-control study of elderly patients with acute respiratory illness: effect of influenza vaccination on admission to hospital in winter 2003-2004
Jordan, RE and Hawker, JI and Ayres, JG and Tunnicliffe, W and Adab, P and Olowokure, B and Kai, J and McManus, RJM and Salter, RA and Cheng, KK (2007) A case-control study of elderly patients with acute respiratory illness: effect of influenza vaccination on admission to hospital in winter 2003-2004. Vaccine, 25 (46). pp. 7909-13. ISSN 0264-410X
URL of Published Version: http://dx.doi.org/10.1016/j.vaccine.2007.09.005
Identification Number/DOI: 10.1016/j.vaccine.2007.09.005
Every winter, hospitals face a large increase in emergency respiratory admissions in elderly people. A case-control study was undertaken to assess the effect of routine influenza vaccine in preventing such admissions among a cohort of UK elderly presenting with acute respiratory illness during winter 2003-2004. 157 hospitalised cases and 639 controls (matched for age, sex and week of consultation) were interviewed. In a winter typical of levels of circulating influenza in recent years, influenza vaccine did not show a protective effect on emergency respiratory admissions overall (adjusted OR 1.2 (95%CI 0.8, 1.9). Policy makers should not rely solely on influenza vaccine routinely having a large effect on winter pressures, and should focus on additional preventive strategies.
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